SNPs and polygenic disorders: a less gloomy view

The Science at Croatian Universities: a Gloomy View through SCIsearch and MEDLINE*

Aim. Comparison of scientific articles published during the last 10 years by scientists working at the universities of Zagreb, Rijeka, Osijek and Split (Croatia), Ulm (Germany) and Graz (Austria). Method. Analysis of the numbers of papers ob­ tained by searching the SCIsearch database of the Institute for Scientific Information (ISI) and MEDLINE. Results. The universities of Osijek, Rijeka and ...

Numerical Taxonomy of Birth Defects and Polygenic Disorders

This volume contains papers presented at a conference held at the Jackson Laboratory in 1976 under the auspices of the National Foundation. The papers deal with several extremely interesting observations and ideas that support the notion that senescence is genetically controlled. Even if the reader has not been previously acquainted with the literature on aging, this book will provide a readabl...

Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement

Despite evidence of substantial comorbidity between psychiatric disorders and substance involvement, the extent to which common genetic factors contribute to their co-occurrence remains understudied. In the current study, we tested for associations between polygenic risk for psychiatric disorders and substance involvement (i.e., ranging from ever-use to severe dependence) among 2573 non-Hispani...

Gloomy in Glenburn.

An Expanded View of Complex Traits: From Polygenic to Omnigenic.

A central goal of genetics is to understand the links between genetic variation and disease. Intuitively, one might expect disease-causing variants to cluster into key pathways that drive disease etiology. But for complex traits, association signals tend to be spread across most of the genome-including near many genes without an obvious connection to disease. We propose that gene regulatory net...